I agree that from a prestige standpoint University of Phoenix etc. may not be the cat's meow, but really, looking at the wasteland downtown is, beggars can't be choosers. And as Kraze already noted, we already screwed the pooch and ran off a med school and a law school who were both considering locating downtown. Both of those institutions then went on to invest tens of millions of dollars fitting out single-purpose buildings located elsewhere, so I really don't think there is a second chance. Those were both 1-shot deals for downtown, that goose is cooked, we screwed it up.
What I'm saying is, at this point, if a University of Phoenix or Devry or whatever wanted to open up down there, then we should welcome them with open arms. It's not like we have a lot of other suitors. Especially after the way the last two were treated, and it's not like educators don't talk to each other. Whatever comes knocking, we need to accept it for what it is rather than holding out for something better, that usually never happens. Look at Springfield, they're staring down a blighted and almost totally-vacant commercial district, while SPAR still waits on their Starbucks and Panera Bread that never showed up after they ran off all the "lesser" merchants they didn't like.
At this point, something is better than nothing.